Moisture Plus Solutions for the Pharmaceutical Industry

Raw Materials Identification and Qualification

Metrohm NIR analyzers save you time and money by reducing the quality control lab burden and speeding material acceptance. Insensitive to fluorescence, NIR spectroscopy is ideal for validating incoming raw materials, quantifying components of incoming mixtures, and inspecting natural products. An established spectroscopy technology, NIR is recommended by the FDA and USP as a part of technology modernization and PAT. Raw materials identification and qualification is called out in several USP monographs, including general chapter <1119>.

Measure the following with NIR Spectroscopy:

• Solvents
• Powders
• Excipients
• Active pharmaceutical ingredients

Resources:

• Webinars: Optimized QC with NIRS, A New Approach to Handheld Raman
• Application Note: Identification of 46 medicinal and aromatic plants for the cosmetics and pharmaceuticals industry
• Application Bulletin: Pharmaceutical analysis using near-infrared spectroscopy

Laboratory and At-Line Analysis

Stop wasting product and consuming both time and reagents for routine testing. Modernize your analysis by using non-destructive, preparation free Metrohm NIR technology. Our analyzers feature dedicated sampling accessories that provide the highest signal to noise ratios for better sensitivity, letting you measure more parameters to lower levels – all with the same accuracy and precision as the primary USP methods.

Measure moisture in: Lyophilized products, solvents, precursors, solid dosage forms, and ongoing reactions

Typical Moisture Plus applications: API concentration, blend uniformity, coating thickness, content uniformity, dissolution profile, product stability, roller compaction hardness

Measure moisture in: Lyophilized products, ongoing reactions, solvents, solids

Typical Moisture Plus applications: Active ingredient concentration, blend uniformity, coating thickness, content uniformity, dissolution profile, roller compaction hardness, stability testing.

Webinars:

• Moisture+ Analysis: Fast and Reliable Near-IR Analysis Beyond Water
• Increasing Uptime for Karl Fischer and Spectroscopy Moisture Analysis
• Fast and Nondestructive Moisture Analysis of Lyophilized Products

• Determination of polymorphous sulfathiazoles by near-infrared spectroscopy (NIR)
• Near-infrared (NIR) assay and content uniformity of tablets NIR “predictive model” for the release of pharmaceutical active ingredients from solid dosage forms
• Following the progress of pharmaceutical mixing studies using near-infrared spectroscopy
• Nondestructive, single tablet analysis using the NIRS XDS RapidContent Analyzer

Process Analytical Technology

Know and adapt in real-time with process NIR spectroscopy. Eliminate the long wait for lab results and remove the risk of sample contamination by making measurements directly in the production process. From premix to packaging, Metrohm Moisture Plus ensures product consistency and quality, all while meeting cGMP requirements.

With sampling tools developed specifically for the pharmaceutical industry, such as the purge (spoon) probe for collecting samples during drying and granulation, and up to 9 measurement channels, the one XDS analyzer can monitor the full scope of continuous or batch processes.

Webinars:

• Moisture+ Analysis: Fast and Reliable Near-IR Analysis Beyond Water
• Increasing Uptime for Karl Fischer and Spectroscopy Moisture Analysis
• Fast and Nondestructive Moisture Analysis of Lyophilized Products